Abstract
Background
Chronic activation of the sympathoadrenal system plays an important role in the development of pancreatic dysfunction. However, morphological mechanisms underlying endocrine and exocrine pancreatic adaptation to prolonged adrenaline exposure remain insufficiently investigated.
Objective.To evaluate morphological, morphometric, and immunohistochemical changes in the pancreas of rats subjected to prolonged adrenaline-induced stress.
References
1. Selye H. Stress and the General Adaptation Syndrome.
2. McEwen BS. Protective and damaging effects of stress mediators.
3. Eizirik DL et al. The pancreatic beta-cell in stress adaptation.
4. Donath MY. Inflammation and pancreatic dysfunction.
5. Bonner-Weir S. β-cell growth and regeneration.
6. Ashcroft FM. Glucose sensing in pancreatic β-cells.
7. American Diabetes Association Standards of Care.
8. Saisho Y. β-cell adaptation and failure.
9. Robertson RP. Oxidative stress and β-cell dysfunction.
10. Rorsman P. Pancreatic endocrine physiology.