Keywords
Abstract
Surunkali gastrit (SG) me'da shilliq pardasining uzoq muddatli yallig‘lanish kasalligi bo‘lib, butun dunyo bo‘ylab millionlab odamlarga ta’sir etadi. Jahon sog‘liqni saqlash tashkiloti (JSST) ma'lumotlariga ko‘ra, SGning tarqalishi rivojlanayotgan mamlakatlarda 50-70% gacha yetadi, chunki Helicobacter pylori (H. pylori) infeksiyasi yuqori. Kasallikning asosiy sabablari orasida H. pylori infeksiyasi (90% holatlarda), autoimmun jarayonlar (masalan, A tipidagi gastrit), noto‘g‘ri ovqatlanish (spirtli ichimliklar, qaynoq ovqatlar, NSAID dorilar), stress, ekologik omillar va genetik predispozitsiya mavjud. SGning turlari - surunkali atrofiyali gastrit (SAG) (atrofiya va intestinal metaplasiya bilan), surunkali non-atrofiyali gastrit (SNAG) (superficial yallig‘lanish bilan) va maxsus turlar (eozinofil, limfotsitar gastrit) - har biri o‘ziga xos simptomlarga ega. Simptomlar orasida epigastral og‘riq, dispepsiya, meteorizm, anemiya (atrofiyada B12 vitamin yetishmovchiligi sabab), qayt qilish, ko‘ngil aynishi va uzoq muddatda me'da saraton xavfi oshishi kuzatiladi. Epidemiologik tadqiqotlar shuni ko‘rsatadiki, SAG me'da saratonining 80% holatlarida saraton (rak) rivojlanishidan oldingi holat sharoit hisoblanadi (Correa kaskadi bo‘yicha). An'anaviy davolashda proton pompasi inhibitorlari (PPI) (omeprazol, esomeprazol), antibiotiklar (amoksitsillin, klaritromitsin), gastroprotektorlar (rebamipid, sukralfat) va H. pylori eradikatsiyasi uchun kvadruple terapiya (vismut bilan) ishlatiladi. Biroq, ularning cheklovlari bor: antibiotik rezistentligi oshishi (2025 yilgi ma'lumotlar bo‘yicha, Evropada 30%), yon ta’sirlar (disbioz, osteoporoz, infeksiya xavfi oshishi) va remissiya davomiyligi qisqa. 2023-2026 yillardagi dolzarb tadqiqotlar shuni ko‘rsatadiki, PPI ning uzoq muddatli qo‘llanilishi me'da shilliq pardasida metaplaziyani kuchaytirishi mumkin. Shu sababli, fizioterapiya (FT) kabi qo‘shimcha usullar dolzarblashmoqda. FT me'da qon aylanishini yaxshilaydi, yallig‘lanish mediatorlarini (IL-6, TNF-α, COX-2) kamaytiradi, parasimpatik tizimni faollashtiradi, gut-brain axisni regulyatsiya qiladi va hayot sifatini oshiradi. Masalan, 2025 yilgi meta-tahlillar akupunktura va massaj terapiyasini SAGda samarali deb ko‘rsatgan, simptomlarni 87-96% kamaytirgan va me'da funksiyasini yaxshilagan.
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