Keywords
Abstract
Shershevskiy–Turner sindromi (ShTS) — ayol jinsiga xos bo‘lgan, X xromosomaning to‘liq yoki qisman yetishmasligi bilan bog‘liq genetik kasallik bo‘lib, embrional rivojlanish davrida yuzaga keladi. Ushbu sindromning asosiy genetik shakli 45,X0 kariotipi bo‘lib, u barcha holatlarning taxminan 50–60 foizini tashkil etadi. Qolgan bemorlarda mozaik (45,X0/46,XX) yoki X xromosomaning struktur o‘zgarishlari bilan kechuvchi shakllar aniqlanadi [1, 7; 3, 116]. Genetik nuqson natijasida gonadal disgeneziya rivojlanib, tuxumdonlarning normal shakllanishi buziladi, bu esa reproduktiv funksiyaning yetishmasligiga olib keladi.
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