Vol. 3 No. 8 (2025), Articles
Vol. 3 No. 8 (2025)

BIOPHYSICAL MECHANISMS OF MUSCLE CONTRACTION

Articles
Published 2025-12-17
Ubaydullayeva Vazira Patchakhanovna
Tashkent State Medical University
Sabitova Tamanno Oybek qizi
1st-year students of General Medicine Tashkent State Medical University
Otamurodova Maftuna Shaymurod qizi
1st-year students of General Medicine Tashkent State Medical University
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Keywords

muscle contraction; biophysics; actin–myosin interaction; contractile proteins; mechanochemical energy conversion; calcium regulation; sarcomere; action potential; neuromuscular transmission; cross-bridge cycle; contraction force; tetanic contraction; muscle biomechanics; molecular mechanisms; energy metabolism.

Abstract

In this article, muscle contraction is considered from a biophysical perspective as a complex process of converting chemical energy into mechanical work, carried out through the coordinated interaction of protein structures within muscle fibers. This process is of fundamental importance for understanding the mechanisms of motor activity, regulation of physiological functions, and adaptation to physical нагрузкам. The analysis of biophysical mechanisms of muscle contraction makes it possible to reveal the features of molecular interactions that determine the strength, speed, and stability of contractions in different types of muscle tissue.

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References

1. Rassier, D.E. Muscle Biophysics: From Molecules to Cells. Springer, 2014.

2. Squire, J.M. (Ed.) Molecular Mechanisms in Muscular Contraction. Academic Press, 2018.

3. Frank, K., Bianchi, G., Keurs, H.E. Excitation–Contraction Coupling in Skeletal, Cardiac, and Smooth Muscle. Oxford University Press, 2016.

4. Bagshaw, C.R. Muscle Contraction: Mechanisms and Biophysics. Cambridge University Press, 2012.

5. Rüegg, J.C. Calcium in Muscle Contraction: Regulation and Biophysical Mechanisms. Springer, 2015.

6. Sugi, H. (Ed.) Muscle Contraction and Cell Motility: Molecular and Biophysical Perspectives. Wiley, 2017.

7. Марасулов, А. Ф., Базарбаев, М. И., Сайфуллаева, Д. И., & Сафаров, У. К. (2018). Подход к обучению математике, информатике, Информatsiонным технологиям и их интегрatsiи в медицинских вузах. Вестник ташкентской медицинской академии, (2), 42.

8. Fayziyeva, N. A. (2025). OLIY TA’LIMDA PEDAGOGIK TA’LIM-TARBIYANI TASHKIL ETISHNING AHAMIYATLARI VA ZAMONAVIY METODLARIDAN FOYDALANISH USULLARI.

9. Baxtiyorovna, E. D., Alisherovna, F. N., & Jurayeva, U. O. N. (2024). PROPERTIES OF ELECTRON AND NEUTRON THERAPY. Web of Medicine: Journal of Medicine, Practice and Nursing, 2(10), 137-141.

10. Fayziyeva, N. (2025). THE EFFECT OF MAGNESIUM ON PREGNANT WOMEN. Web of Medicine: Journal of Medicine, Practice and Nursing, 3(5), 60-63.

11. Fayziyeva, N. (2025). THE INTENSITY OF DIABETES CASES AMONG THE POPULATION OF BUKHARA REGION OVER THE PAST 5 YEARS. International journal of medical sciences, 1(1), 158-161.

12. Sobirova, D. R., Usmanov, R. D., Po’latov, X. X., Azizova, F. X., & Akbarova, M. N. (2023). QANDLI DABET KASALLIGIDA O ‘PKA ENDOTELIYIDAGI GISTOLOGIK O ‘ZGARISHLAR.

13. Собирова, Д. Р., Нуралиев, Н. А., Усманов, Р. Д., Азизова, Ф. Х., & Пулатов, Х. Х. (2023). СОЯ УНИНИНГ ОЗУҚАВИЙ ҚИЙМАТИ, МИКРОЭЛЕМЕНТЛАР ВА РАДИОНУКЛИДЛАР КЎРСАТГИЧЛАРИ (24-СОНЛИ). «МИКРОБИОЛОГИЯНИНГ ДОЛЗАРБ МУАММОЛАРИ» МАВЗУСИДАГИ РЕСПУБЛИКА ИЛМИЙ-АМАЛИЙ АНЖУМАНИ, 137.

14. Nishanov, D. A., Kh, P. K., Sobirova, D. R., & Matrasulov, R. S. (2023). MODERN DIAGNOSIS OF NEPHROBLASTOMA IN CHILDREN. Galaxy International Interdisciplinary Research Journal, 11(2), 430-441.

15. Закиров, А. У., Пулатов, Х. Х., & Исмалов, Д. Д. (2001). Изучение противовоспалительных свойств диклозана. Экспер. и клин. фарм, (5), 50-52.

16. Пулатов, Х. Х. (2022). Влияние экспериментального сахарного диабета на надпочечники: дис. Ўзбекистон, Самарқанд.

17. Adilbekova, D. B., Usmanov, R. D., Mirsharapov, U. M., & Mansurova, D. A. (2019). MORPHOLOGICAL STATE OF EARLY POSTNATAL FORMATION OF THE ORGANS OF THE GASTROINTESTINAL TRACT AND LIVER IN OFFSPRING BORN AND RAISED BY MOTHERS WITH CHRONIC TOXIC HEPATITIS. Central Asian Journal of Medicine, 4, 43-55.

18. Адилбекова, Д. Б., Хатамов, А. И., Мансурова, Д. А., & Пулатов, Х. Х. (2020). Морфологическое состояние сосудисто-тканевых структур желудка у потомства в условиях хронического токсического гепатита у матери. Морфология, 157(2-3), 10-11.

19. Adilbekova, D. B. (2018). Postnatal formation of vascular-tissue structures of the stomach and intestines of offspring in conditions of chronic toxic hepatitis in the mother. Abstract. Autoref. dis.... doctor of medical Sciences. TMA, Tashkent.-2018.-26 p.

20. Абдураззоков, Х., Адилбекова, Д., Боймаков, С., & Ибрагимова, М. (2022). Морфологические аспектқ кишечной недостаточности при экспериментальном перитоните.

21. Назарова, М., Адилбекова, Д., & Исаева, Н. (2021). Морфологическое состояние печени у потомства, в условиях хронического токсического гепатита у матери. Журнал биомедицины и практики, 1(1), 52-57.