Vol. 3 No. 5 (2025), Articles
Vol. 3 No. 5 (2025)

THE RELATIONSHIP BETWEEN OBESITY AND DIABETES

Articles
Published 2025-11-12
Tirkasheva Noila Ergash qizi
Trainee Assistant at SAMARKAND STATE MEDICAL UNIVERSITY
Asatullayev Rustamjon Baxtiyarovich
Trainee Assistant at SAMARKAND STATE MEDICAL UNIVERSITY
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Keywords

obesity, diabetes mellitus, insulin resistance, metabolic syndrome, adipokines, prevention

Abstract

The global rise in obesity has led to a corresponding increase in the prevalence of diabetes mellitus, particularly type 2 diabetes. The connection between these two metabolic disorders is multifactorial, involving complex interactions between genetic, hormonal, inflammatory, and behavioral factors. Obesity contributes to insulin resistance, impaired glucose tolerance, and chronic hyperglycemia, all of which play a pivotal role in the pathogenesis of diabetes. This paper discusses the pathophysiological mechanisms linking obesity to diabetes, epidemiological trends, clinical implications, and preventive strategies aimed at reducing the global burden of these interrelated diseases.
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References

1. World Health Organization. Obesity and overweight: key facts. WHO, 2024.

2. American Diabetes Association. Standards of Medical Care in Diabetes – 2025. Diabetes Care. 2025;48(Suppl 1):S1-S188.

3. Kahn SE, Hull RL, Utzschneider KM. Mechanisms linking obesity to insulin resistance and type 2 diabetes. Nature. 2006;444:840-846.

4. Shoelson SE, Herrero L, Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterology. 2007;132(6):2169-2180.

5. Frühbeck G, Catalán V, Rodríguez A, Gómez-Ambrosi J. Adiponectin–leptin ratio as a biomarker of adipose tissue inflammation. J Physiol Biochem. 2019;75:201-210.

6. Locke AE et al. Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015;518:197-206.

7. Bhupathiraju SN, Hu FB. Epidemiology of obesity and diabetes and their cardiovascular consequences. Circ Res. 2016;118:1723-1735.

8. Eckel RH, Kahn SE, Ferrannini E, Goldfine AB. Obesity and type 2 diabetes: what can be unified and what needs to be individualized? J Clin Endocrinol Metab. 2022;107(9):2579-2591.

9. Tamirisa K.P., Vaidya V.R., van Hagen I.M., et al. Metabolic risk factors in reproductive-age women with diabetes and obesity. Int J Obstet Gynecol. 2023;161:112-120.

10. WHO Global Report on Diabetes. Geneva: World Health Organization; 2023.

11. Chatterjee S, Khunti K, Davies MJ. Type 2 diabetes. Lancet. 2017;389:2239-2251.

12. Tam CS, Xie W, Johnson WD et al. Defining insulin resistance from obesity-related phenotypes. Diabetes Care. 2021;44:1738-1746.