THE RELATIONSHIP BETWEEN OBESITY AND DIABETES
PDF

Keywords

obesity, diabetes, insulin resistance, metabolism, prevention, public health

Abstract

Obesity and diabetes are major public health concerns worldwide, closely linked through complex physiological and metabolic mechanisms. Excess body fat, particularly visceral adiposity, contributes to insulin resistance, impaired glucose tolerance, and ultimately the development of type 2 diabetes mellitus (T2DM). This paper explores the relationship between obesity and diabetes, analyzing their shared pathophysiology, risk factors, and preventive strategies. Findings indicate that lifestyle modification—such as balanced nutrition, regular exercise, and weight management—is the most effective approach to reducing the global burden of both conditions.

PDF

References

1. World Health Organization. (2023). Obesity and overweight: Key facts. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight

2. American Diabetes Association. (2023). Standards of Medical Care in Diabetes. Diabetes Care, 46(Suppl 1), S1–S301.

3. Eckel, R. H., Kahn, S. E., & Ferrannini, E. (2020). Obesity and Type 2 Diabetes: Mechanisms and Clinical Implications. The Lancet, 395(10223), 65–79.

4. Hall, J. E., & Hall, M. E. (2020). Guyton and Hall Textbook of Medical Physiology (14th ed.). Elsevier.

5. Hu, F. B. (2017). Globalization of Diabetes: The Role of Diet, Lifestyle, and Genes. Diabetes Care, 34(6), 1249–1257.

6. Centers for Disease Control and Prevention (CDC). (2023). National Diabetes Statistics Report.

7. Bray, G. A., & Ryan, D. H. (2021). Medical Consequences of Obesity. Journal of Clinical Endocrinology & Metabolism, 106(2), e381–e390.

8. Kahn, B. B., & Flier, J. S. (2021). Obesity and Insulin Resistance. Journal of Clinical Investigation, 131(1), e142896.