Vol. 3 No. 3 (2025), Articles
Vol. 3 No. 3 (2025)

METABOLIC CHANGES IN CANCER CELLS AND THE WARBURG EFFECT

Articles
Published 2025-09-23
Fayziyev |Farrux Sharifovich
Tibbiyot fanlar nomzodi dotsent
Rahmonova Umida Tohir qizi
Toshkent davlat tibbiyot unversiteti talabasi
Abdumannonova Xidoyatxon G’anisher qizi
Toshkent davlat tibbiyot unversiteti talabasi
Botirova Farangiz O’ktam qizi
Toshkent davlat tibbiyot unversiteti talabasi
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Keywords

Cancer metabolism, Warburg effect, aerobic glycolysis, HIF-1α, MYC, PI3K/AKT/mTOR pathway, mitochondrial dysfunction, glycolysis inhibitors, metabolic therapy.

Abstract

Background: Cancer cells maintain their growth and viability through metabolic changes. One of their main features is the Warburg effect, i.e., their preference for glycolysis over oxidative phosphorylation for energy production, even when oxygen is sufficient. This phenomenon is associated with oncogene activation, inactivation of tumor suppressor genes, hypoxia-inducible factors, and other factors.

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References

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