Keywords
Abstract
Ushbu maqolada qon tomir protezlarining zamonaviy biokompatibil materiallar bilan almashtirilishi natijasida kuzatilgan eksperimental va klinik ko‘rsatkichlar tahlil qilingan. Protez materiallarining biotuzilmasi, gemodinamik mosligi, to‘qimalar bilan integratsiyasi va yallig‘lanish reaksiyasini keltirib chiqarmasligi — ularning muvaffaqiyatli qo‘llanilishining asosiy omillaridir. Tadqiqotda turli xil polimer, kompozit va nanostrukturali materiallar asosida ishlab chiqarilgan protezlarning hayvonlar ustidagi tajribalari hamda klinik bemorlar guruhidagi amaliy qo‘llanish tajribalari solishtirildi. Natijalar shuni ko‘rsatdiki, ilg‘or biokompatibil materiallar trombogenez xavfini kamaytiradi, protezning uzoq muddatli faoliyatini ta’minlaydi va qayta operatsiya ehtimolini sezilarli darajada pasaytiradi.
References
1. Brown, M. A., & Green, R. (2021). Advances in Vascular Graft Biocompatibility: From Material Science to Clinical Application. Journal of Biomedical Materials Research, 109(4), 872–889.
2. Kachlany, S. C., et al. (2020). Biodegradable vascular grafts: a review of materials and design. Cardiovascular Engineering and Technology, 11(3), 321–334.
3. Malakhov, A. O., & Petrov, N. I. (2019). Clinical outcomes of PTFE and Dacron grafts in arterial reconstruction: A comparative study. Russian Journal of Vascular Surgery, 8(1), 45–51.
4. Zhang, Y., et al. (2022). Nanocomposite coatings for vascular grafts: reducing thrombogenicity and promoting endothelialization. Materials Science and Engineering: C, 128, 112287.
5. World Health Organization (WHO). (2023). Global Status Report on Cardiovascular Diseases.
6. Rakhimov, O. A., & To‘xtasinov, B. T. (2021). Yurak-qon tomir protezlarida biokompatibil materiallar qo‘llanishining dolzarb masalalari. O‘zbekiston Tibbiyot Jurnali, 2(135), 56–61.
7. Sun, W., & Wang, Z. (2023). 3D Bioprinting in Cardiovascular Medicine: A New Era for Personalized Vascular Grafts. Frontiers in Bioengineering and Biotechnology, 11, 1175312.