Abstract
The cardiovascular system, a vital network for nutrient and gas exchange, operates under the precise and dynamic control of the autonomic nervous system (ANS). This review explores the intricate interplay between sympathetic and parasympathetic branches of the ANS and their profound influence on cardiovascular homeostasis. We delve into the mechanisms by which the ANS regulates heart rate, contractility, vascular tone, and blood pressure, highlighting key receptors and signaling pathways. Furthermore, we discuss the implications of dysregulation in various pathophysiological states, including hypertension, heart failure, and autonomic neuropathies. Understanding these complex interactions is crucial for developing targeted therapeutic strategies to maintain cardiovascular health.
References
1. Berne, R. M., & Levy, M. N. (2009). Physiology (6th ed.). Mosby Elsevier.
2. Boron, W. F., & Boulpaep, E. L. (2017). Medical Physiology (3rd ed.). Elsevier.
3. Floras, J. S. (2009). Sympathetic nervous system activation in human heart failure: clinical implications of an updated comparison of direct and indirect recording approaches. Journal of the American College of Cardiology, 54(5), 375-385.
4. Guyton, A. C., & Hall, J. E. (2016). Textbook of Medical Physiology (13th ed.). Saunders Elsevier.
5. Levick, J. R. (2010). An Introduction to Cardiovascular Physiology (5th ed.). Hodder Arnold.
6. Mancia, G., Fagard, R., Narkiewicz, K., Redón, J., Zanchetti, A., Böhm, M., ... & Zannad, F. (2013). 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). Journal of Hypertension, 31(7), 1281-1357.
7. Pop-Busui, R., Boulton, A. J. M., Feldman, E. L., Lott, A. L., Parsons, M., Smith, B., & Whitehouse, F. (2017). Diabetic neuropathy: A position statement by the American Diabetes Association. Diabetes Care, 40(1), 136-154.
8. West, J. B. (2012). Pulmonary Physiology and Pathophysiology (8th ed.). Lippincott Williams & Wilkins.