Vol. 3 No. 1 (2025), Articles
Vol. 3 No. 1 (2025)

AVLODLAR ZANJIRIDA PODAGRA: IRSIYLIK VA KASALLIK CHASTOTASI

Articles
Published 2025-06-18
Bekmurodova Malika Roʻzimurod qizi
Samarqand davlat tibbiyot universiteti, 2-son Davolash ishi fakultetining 5-bosqich talabasi
Tursunkulova Durdona Shuxrat qizi
Samarqand davlat tibbiyot universiteti, Pediatriya fakultetining 4- bosqich talabasi
To'layev Bobur Zoyir o'g'li
Samarqand Davlat Tibbiyot Universiteti , Pediatriya fakulteti 5-bosqich talabasi
Toirov Doston Rustamovich
Ilmiy rahbar : Samarqand davlat tibbiyot universiteti, Ichki kasalliklar propedivtikasi kafedrasi dotsenti, PhD
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Keywords

Podagra, siydik kislotasi, giperurikemiya, genetik xavf omillari, metabolik sindrom, GWAS, SLC2A9, ABCG2 geni, genetik polimorfizm, nasliy penetrantlik

Abstract

Podagra – purin almashinuvining buzilishi natijasida yuzaga keladigan surunkali metabolik kasallik bo‘lib, ko‘pincha bo‘g‘imlarda yallig‘lanish va og‘riqli tutqanoqlar bilan namoyon bo‘ladi. So‘nggi yillarda podagra bilan kasallanish holatlarining oilaviy guruhlarda yuqori uchrashi, kasallikning genetik omillar bilan chambarchas bog‘liqligini ko‘rsatmoqda. Aynan shuning uchun ham kasallikning avlodlar zanjirida qanday tezlikda va qaysi omillar ta’sirida rivojlanishini o‘rganish zarurati ortmoqda. Ushbu mavzuni tadqiq etish orqali podagraga genetik moyilligi bo‘lgan shaxslarni erta aniqlash, individual profilaktika choralarini ishlab chiqish va nasliy xavf guruhlarini belgilash imkoniyati yaratiladi. Tadqiqotning natijalari kelajakda shaxsiylashtirilgan tibbiyot yondashuvlarini joriy etish va podagra bilan bog‘liq asoratlarni oldini olishda muhim ilmiy-amaliy ahamiyat kasb etadi.

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