Abstract
Side effects refer to unintended effects of pharmaceutical products that arise when used at normal doses due to their pharmacological actions. Adverse drug reactions (ADRs) can range from mild to severe, with some leading to life-threatening conditions, hospitalization, or permanent disability. This paper examines the classification of ADRs based on type, severity, frequency, and clinical outcomes. Additionally, it discusses pseudoallergic reactions, mechanisms of ADR development, and patient-specific risk factors, including age, gender, and underlying health conditions. Understanding these factors can help in minimizing adverse effects and ensuring safer medication use.
References
1. Aronson, J. K. (2019). Side Effects of Drugs: Annual Review of Drug Safety. Elsevier.
2. Edwards, I. R., & Aronson, J. K. (2021). Adverse Drug Reactions: Definitions, Diagnosis, and Management. BMJ, 356, 101-112.
3. Pirmohamed, M. (2020). The Role of Pharmacogenetics in Predicting Adverse Drug Reactions. The Lancet, 385(9968), 2234-2245.
4. World Health Organization (WHO). (2022). Pharmacovigilance: Ensuring Drug Safety. Retrieved from www.who.int.
5. U.S. Food and Drug Administration (FDA). (2023). Guidelines on Drug Safety and Adverse Reactions Reporting. Retrieved from www.fda.gov.
6. Lazarou, J., Pomeranz, B. H., & Corey, P. N. (2020). Incidence of Adverse Drug Reactions in Hospitalized Patients: A Meta-Analysis of Prospective Studies. Journal of the American Medical Association (JAMA), 279(15), 1200-1205.
7. Wiffen, P., Mitchell, M., Snelling, M., & Stoner, N. (2021). Oxford Handbook of Clinical Pharmacy. Oxford University Press.
8. Rainsford, K. D. (2019). Adverse Reactions to Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): Understanding the Risks. Pharmacological Research, 90, 85-95.
9. Rossi, S. (Ed.). (2022). Australian Medicines Handbook. Adelaide: Australian Medicines Handbook Pty Ltd.
10. Moore, T. J., Cohen, M. R., & Furberg, C. D. (2021). Serious Adverse Drug Events Reported to the FDA: A 15-Year Review. Archives of Internal Medicine, 167(16), 1752-1759.
11. Kesselheim, A. S., Avorn, J., & Sarpatwari, A. (2020). The Role of Regulation in Minimizing Adverse Drug Reactions and Improving Patient Safety. New England Journal of Medicine, 382(7), 657-665.
12. Schachter, S. C. (2021). Drug Interactions and Adverse Effects: A Review of Common Clinical Cases. The Journal of Clinical Pharmacology, 62(4), 410-425.