Keywords
Abstract
Antimikrob rezistentlik (AMR) zamonaviy tibbiyot va farmatsevtika oldida turgan eng murakkab global muammolardan biri bo‘lib, mikroorganizmlarning ularga qarshi qo‘llaniladigan antimikrob preparatlar ta’siriga chidamlilik xususiyatini rivojlantirishi bilan tavsiflanadi. Ayniqsa, antibiotiklarga chidamli bakteriyalarning ko‘payishi infeksion kasalliklarni davolash samaradorligini pasaytirib, shifoxonada davolanish muddatining uzayishi, asoratlar, davolash xarajatlarining ortishi va og‘ir klinik oqibatlar xavfining kuchayishiga olib kelmoqda. Jahon sog‘liqni saqlash tashkilotining 2025-yilgi global kuzatuv hisobotida 2023-yil ma’lumotlari asosida 23 milliondan ortiq bakteriologik tasdiqlangan holat tahlil qilingan bo‘lib, bu AMRning global miqyosdagi real epidemiologik ahamiyatini ko‘rsatadi. Mazkur maqolada antibiotiklarga rezistentlikning shakllanish mexanizmlari, uning asosiy sabab va xavf omillari hamda farmatsevtikaning ushbu muammoga qarshi kurashdagi strategik o‘rni tahlil qilinadi. Antibiotiklarni oqilona qo‘llash, antimikrob stewardship dasturlarida farmatsevt ishtiroki, dori vositalarining sifatini ta’minlash, farmakovigilans, antibiotiklar iste’molini monitoring qilish, mikrobiologik diagnostika natijalaridan foydalanish va yangi antimikrob preparatlarni yaratishning ilmiy yo‘nalishlari yoritiladi. Shuningdek, WHO AWaRe tasnifi asosida antibiotiklardan foydalanishni optimallashtirish, “Access–Watch–Reserve” tamoyillarining farmatsevtik amaliyotdagi ahamiyati ko‘rib chiqiladi. Tahlil natijalari farmatsevtni faqat dori vositasini beruvchi mutaxassis sifatida emas, balki antimikrob terapiyaning xavfsizligi va ratsionalligini ta’minlovchi klinik jamoaning muhim a’zosi sifatida qarash zarurligini ko‘rsatadi. Farmatsevtik nazorat, raqamli monitoring, farmakovigilans, aholining tibbiy savodxonligini oshirish va innovatsion antimikrob preparatlarni ishlab chiqish AMRning tarqalishini cheklashda o‘zaro bog‘liq strategiyalar sifatida qaralishi lozim.
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