Keywords
Abstract
Ikkinchi tip qandli diabet global sog‘liq uchun jiddiy muammo bo‘lib, glyukoza metabolizmining buzilishi bilan tavsiflanadi. So‘nggi tadqiqotlar epigenetik o‘zgarishlar, xususan deoksiribonuklein kislotaning metillanishi, bu kasallikning rivojlanishida muhim rol o‘ynashini ko‘rsatadi. Deoksiribonuklein kislotaning metillanishi genlarning faoliyatini boshqaradi va shu jumladan insulin ishlab chiqarish va glyukoza darajasini nazorat qiluvchi genlarni ham o‘z ichiga oladi. Ikkinchi tip qandli diabet kasalligida metillanish profili o‘zgaradi, ayniqsa pankreas beta hujayralarida va to‘qimalarda insulin qarshiligi bilan bog‘liq genlarda kuzatiladi. Ushbu maqolada deoksiribonuklein kislotaning metillanish jarayoni, uning diabet rivojlanishidagi mexanizmlari va davolashda epigenetik yondashuvlarning ahamiyati tahlil qilinadi.
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