Keywords
Abstract
So‘nggi yillarda psixoemotsional stressning endokrin tizimga, xususan qalqonsimon bez funksiyasiga ta’siri ilmiy-amaliy jihatdan dolzarb muammo sifatida baholanmoqda. Stress holatida gipotalamo-gipofizar-buyrak usti (HPA) o‘qi faollashishi natijasida kortizol sekretsiyasi ortadi va bu holat gipotalamo-gipofizar-qalqonsimon bez (HPT) tizimi orqali tireotrop gormon (TSH) sekretsiyasiga, periferik to‘qimalarda tiroksin (T4) va triyodtironin (T3) konversiyasiga hamda immun-regulyator mexanizmlarga sezilarli ta’sir ko‘rsatishi mumkin. Klinik kuzatuvlarga ko‘ra, surunkali stress fonida subklinik gipotireozning namoyon bo‘lishi, tireoid gormonlarining labilligi, shuningdek tireotoksikozda vegetativ va kardiovaskulyar simptomlarning kuchayishi ehtimoli ortadi. Biroq ushbu o‘zaro bog‘liqlik ko‘p omilli bo‘lib, stressning davomiyligi, shaxsning psixofiziologik reaktivligi, autoimmun jarayonlar faolligi, yod almashinuvi va komorbid patologiyalar bilan chambarchas bog‘liqdir. Mazkur maqolada stress va qalqonsimon bez gormonlari o‘rtasidagi patofiziologik munosabatlar, subklinik gipotireoz va tireotoksikozda klinik-laborator ko‘rsatkichlarning o‘zgarish xususiyatlari hamda diagnostik yondashuvlar tahlil qilinadi. Shuningdek, stress omilini baholash, gormonal profil monitoringi va individual terapevtik strategiyalarni optimallashtirishning amaliy ahamiyati yoritib beriladi.
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