Vol. 2 No. 1 (2025), Articles
Vol. 2 No. 1 (2025)

YANGI AVLOD ANTIBAKTERIAL PREPARATLARNING KIMYOVIY TUZILISHI VA FARMAKODINAMIKASI TAHLILI

Articles
Published 2025-10-11
O`ktamova N.B.
Toshken shahar Alfraganus universiteti Tibbiyot fakulteti Davolash ishi yoʻnalishi 3- bosqich talabasi
Boymuratov F.T.
Toshken shahar Alfraganus universiteti Tibbiyot fakulteti farmatsevtika va kimyo kafedrasi dotsenti
PDF

Keywords

Antibakterial preparatlar, kimyoviy tuzilish, farmakodinamika, β-laktamlar, karbapenemlar, oksazolidinonlar, antimikrob rezistentlik, molekulyar modellashtirish, nishonli terapiya.

Abstract

Ushbu maqolada yangi avlod antibakterial preparatlarning kimyoviy tuzilishi, ularning farmakodinamik xususiyatlari hamda bakterial hujayra tuzilmalari bilan o‘zaro ta’siri tahlil qilinadi. Antimikrob rezistentlikning global o‘sishi sharoitida innovatsion antibiotik sinflarini yaratish muhim ilmiy va amaliy vazifalardan biridir. Maqolada β-laktamlar, karbapenemlar, fluorxinolonlar, oksazolidinonlar va lipopeptidlar kabi yangi avlod antibakterial preparatlar misolida ularning molekulyar tuzilishi bilan farmakologik faolligi o‘rtasidagi bog‘liqlik o‘rganilgan. Shuningdek, zamonaviy kimyoviy sintez texnologiyalari, molekulyar modellashtirish usullari va nishonli (targeted) terapiya tamoyillari asosida antibiotiklarning samaradorligini oshirish yo‘llari yoritilgan.

PDF

References

1. Walsh, C. T., & Wencewicz, T. A. (2020). Antibiotics: Challenges, Mechanisms, Opportunities. ASM Press.

2. Wright, G. D. (2019). Molecular mechanisms of antibiotic resistance. Chemical Reviews, 119(6), 2939–2974.

3. Bush, K., & Bradford, P. A. (2020). β-lactams and β-lactamase inhibitors: An overview. Cold Spring Harbor Perspectives in Medicine, 10(8), a025247.

4. Hooper, D. C., & Jacoby, G. A. (2018). Mechanisms of drug resistance: Quinolone resistance. Clinical Infectious Diseases, 67(5), 935–941.

5. Livermore, D. M. (2021). Carbapenem resistance: Mechanisms and epidemiology. Clinical Microbiology Reviews, 34(2), e00032-20.

6. Hashemian, S. M. R., Farhadi, T., & Ganjparvar, M. (2018). Linezolid: A review of its properties, function, and use in critical care. Drug Design, Development and Therapy, 12, 1759–1767.

7. Silver, L. L. (2019). Challenges of antibacterial discovery. Clinical Microbiology Reviews, 32(4), e00012-19.

8. Bassetti, M., Peghin, M., & Vena, A. (2022). Treatment of infections due to resistant gram-positive bacteria. Current Opinion in Infectious Diseases, 35(4), 295–304.

9. Li, X., & Zhang, Y. (2021). Nanotechnology-based antibacterial agents and delivery systems. Advanced Drug Delivery Reviews, 178, 113910.

10. Boymuratov, F. T. (2023). Antimikrob preparatlarning kimyoviy tuzilishi va farmakodinamik xususiyatlari. Toshkent: Alfraganus universiteti nashriyoti.

11. WHO (2022). Global report on antimicrobial resistance. Geneva: World Health Organization.

12. Ventola, C. L. (2019). The antibiotic resistance crisis. Pharmacy and Therapeutics, 44(6), 377–383.