Abstract
OIV (inson immun tanqisligi virusi) infeksiyasi global sog‘liqni saqlash muammosi bo‘lib, so‘nggi o‘n yilliklarda virusning replikatsiyasini bostirishga qaratilgan antiretrovirus terapiya (ART) orqali minglab insonlarning hayoti saqlab qolindi. Zamonaviy ART protokollari yuqori samaradorlik, past toksiklik va uzoq muddatli nazoratga asoslangan bo‘lib, bemorlarning virus yukini aniqlanmaydigan darajaga tushirish va CD4 hujayralar sonini barqarorlashtirishga xizmat qilmoqda. Yaqinda ishlab chiqilgan uzoq ta’sir qiluvchi inyektsion preparatlar, ikki komponentli kombinatsiyalar, va CRISPR-Cas9 asosida genetik terapiya prototiplari HIVni to‘liq davolash istiqbollarini ochib bermoqda. Shuningdek, immunoterapiya va terapevtik vaksinatsiya yo‘nalishidagi tadqiqotlar virusning yashirin rezervuarlarini yo‘qotishga qaratilgan innovatsion yondashuvlarni taqdim etmoqda.
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