Keywords
Abstract
Zamonaviy tibbiyot paradigmasi organizmni yagona integrativ tizim sifatida qaraydi. Og‘iz bo‘shlig‘idagi patologik jarayonlar, ayniqsa surunkali infeksiya o‘choqlari, nafaqat mahalliy, balki tizimli kasalliklarning patogenezida muhim rol o‘ynaydi. Maqsad: Ushbu maqolada stomatologik kasalliklar (xususan, periodontit) va ikkilamchi somatik patologiyalar (yurak-qon tomir kasalliklari, qandli diabet, oshqozon-ichak tizimi patologiyalari) o‘rtasidagi patogenetik va klinik bog‘liqlikni tahlil qilish orqali interdisiplinar yondashuvning ilmiy asoslarini yoritish. Asosiy qoidalar: Surunkali periodontal yallig‘lanish tizimli yallig‘lanish mediatorlari (IL-1β, IL-6, TNF-α, CRP) darajasini oshirib, endoteliya disfunktsiyasi va insulin rezistentligini kuchaytiradi. Bu esa ateroskleroz, diabet dekompensatsiyasi va boshqa metabolik buzilishlar xavfini oshiradi. Bundan tashqari, og‘iz bo‘shlig‘idagi o‘zgarishlar (kserostomiya, eroziya, glossit) ko‘pincha ichki kasalliklarning ilk klinik belgisi bo‘lishi mumkin. Xulosa: Stomatologik va somatik kasalliklar o‘rtasidagi ikki tomonlama patogenetik aloqani tan olish klinik amaliyotda majburiy interdisiplinar hamkorlikni taqozo etadi. Og‘iz bo‘shlig‘idagi surunkali infeksiya o‘choqlarini sanatsiya qilish nafaqat stomatologik, balki umumiy somatik sog‘liqni saqlashning ham muhim tarkibiy qismidir.
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