ATEROSKLEROZ: XAVF OMILLARI VA ULARNI BOSHQARISH YO‘LLARI
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Keywords

Ateroskleroz, koronar arteriya kasalligi, serebrovaskulyar o'zgarishlar, periferik arteriya kasalligi, PZL xolesterin, YZL xolesterin, giperxolesterinemiya, arterial gipertenziya, qandli diabet, dislipidemiya, endotelial disfunksiya, yallig‘lanish, oksidlovchi stress, chekish, semizlik, insulinrezistentlik, jismoniy faollik yetishmasligi, pilakcha, statinlar.

Abstract

Ushbu maqolada aterosklerozning global va mintaqaviy tarqalishi, asosiy xavf omillari va ularni boshqarishning dalillarga asoslangan usullari tahlil qilinadi. Ma’lumotlar JSST, GBD 2019, NCD-RisC va PubMed meta-tahlillaridan yig‘ildi. 40 yoshdan katta 113 milliondan ortiq odamda ateroskleroz aniqlangan va so‘nggi 30 yilda uning uchrash chastotasi 72% ga oshgan. Yuqori PZL, gipertenziya, diabet, chekish, semizlik va gipodinamiya asosiy xavf omillari bo‘lib, ularni statinlar, antigipertenziv va antidiabetik preparatlar hamda sog‘lom turmush tarzi orqali boshqarish mumkin. Milliy skrining dasturlari va profilaktika strategiyalari aterosklerozni  kamaytirishda muhim ahamiyatga ega.

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References

Libby P, et al. Atherosclerosis. Nat Rev Dis Primers. 2019;5(1):56.

2. Benjamin EJ, et al. Heart Disease and Stroke Statistics—2019 Update. Circulation. 2019;139(10):e56–e528.

3. World Health Organization. Cardiovascular diseases (CVDs) fact sheet. Geneva: WHO; 2023.

4. Roth GA, et al. Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019. J Am Coll Cardiol. 2020;76(25):2982–3021.

5. Song P, et al. Global and regional prevalence, burden, and risk factors for carotid atherosclerosis. Lancet Glob Health. 2020;8(5):e721–e729.

6. Herrington W, et al. Epidemiology of Atherosclerosis. Circ Res. 2016;118(4):535–546.

7. GBD 2019 Risk Factors Collaborators. Global burden of 87 risk factors. Lancet. 2020;396(10258):1223–1249.

8. Barquera S, et al. Global Overview of the Epidemiology of Atherosclerotic Cardiovascular Disease. Arch Med Res. 2015;46(5):328–338.

9. NCD-RisC. Worldwide trends in high LDL cholesterol, 1980–2020. Nat Med. 2021;27(8):1385–1398.

10. Pirillo A, et al. Global epidemiology of dyslipidaemias. Atheroscler Suppl. 2021;42:e1–e8.

11. Goldstein JL, Brown MS. A century of cholesterol and coronaries. Cell. 2015;161(1):161–172.

12. Cholesterol Treatment Trialists’ Collaboration. Efficacy and safety of statin therapy in older people. Lancet. 2022;399(10321):207–217.

13. Mozaffarian D, et al. Effects on coronary heart disease of increasing polyunsaturated fat. PLoS Med. 2010;7(3):e1000252.

14. Williams B, et al. 2018 ESC/ESH Guidelines for hypertension. Eur Heart J. 2018;39(33):3021–3104.

15. Ettehad D, et al. Blood pressure lowering for prevention of cardiovascular disease. Lancet. 2016;387(10022):957–967.

16. American Diabetes Association. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes—2023. Diabetes Care. 2023;46(Suppl 1):S158–S190.

17. Emerging Risk Factors Collaboration. Diabetes mellitus, fasting glucose, and risk of cause-specific death. N Engl J Med. 2011;364(9):829–841.

18. Ambrose JA, Barua RS. The pathophysiology of cigarette smoking and cardiovascular disease: an update. J Am Coll Cardiol. 2004;43(10):1731–1737.

19. Hackshaw A, et al. Low cigarette consumption and risk of coronary heart disease and stroke. BMJ. 2018;360:j5855.

20. Expert Panel on Obesity. Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults. Am J Clin Nutr. 1998;68(4):899–917.

21. Lee IM, et al. Physical inactivity and cardiovascular disease risk. Circulation. 2012;126(19):2329–2336.

22. Libby P, et al. Mechanisms of Atherosclerosis. Circulation. 2019;140:271–283.