Vol. 2 No. 8 (2026), Articles
Vol. 2 No. 8 (2026)

ANTIBIOTIK REZISTENTLIK MUAMMOSI VA ZAMONAVIY YECHIMLAR

Articles
Published 2026-02-13
Egamshukurova Sevinch Abdumalik qizi
Samarqand Davlat Tibbiyot Unversiteti talabasi
Toshniyazova Gulruxsor Sherzod qizi
Samarqand Davlat Tibbiyot Unversiteti talabasi
Xayrullayev Po’latjon Asadulloxon o’g’li
Samarqand Davlat Tibbiyot Unversiteti talabasi
O'tkirova Zulxumor Abdurashid qizi
Samarqand Davlat Tibbiyot Unversiteti talabasi
Ne'matova Shahlo Dadajon qizi
Samarqand Davlat Tibbiyot Unversiteti talabasi
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Keywords

antibiotik rezistentlik, MRSA, ESBL, karbapenemaza, effluks pompalar, biofilm, patogenez.

Abstract

Antibiotik rezistentlik (AMR) global sog‘liqni saqlash tizimi oldidagi eng jiddiy tahdidlardan biridir. Rezistent mikroorganizmlar infeksion kasalliklarni davolash samaradorligini pasaytirib, mortalitet va morbiditetni oshirmoqda. O‘zbekistonda antibiotiklarning 70–80% gacha qismi retseptsiz sotilishi¹ selektiv bosimni kuchaytirib, rezistent shtammlar tarqalishiga sabab bo‘lmoqda. Maqolada antibiotik rezistentlikning molekulyar mexanizmlari, klinik ahamiyati, O‘zbekistondagi epidemiologik holat va zamonaviy terapevtik yondashuvlar tahlil qilinadi.

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References

WHO. Antimicrobial resistance in Uzbekistan. 2021.

2. Ministry of Health of Uzbekistan. National AMR monitoring report. 2023.

3. Republican Clinical Microbiology Center. AMR surveillance results 2020–2023.

4. Uzbekistan Pharmaceutical Agency Annual Report. 2024.

5. PQ-4989. Antibiotiklarga chidamlilikni oldini olish to‘g‘risida. 07.02.2023.

6. Murray PR et al. Medical Microbiology. 9th ed. Elsevier; 2023.

7. Mandell, Douglas, and Bennett’s Principles and Practice of Infectious Diseases. 9th ed. 2020.

8. World Bank. Economic impact of antimicrobial resistance. 2022.