Vol. 1 No. 1 (2025), Articles
Vol. 1 No. 1 (2025)

MENTHOL ASOSIDA AYRIM AMINOKISLOTALAR BILAN SINTEZ QILINGAN YANGI BIRIKMALARNING TUZILISHI VA FIZIK-KIMYOVIY XOSSALARINI O‘RGANISH

Articles
Published 2025-07-01
Yettibayeva Lolaxon Abdumalikovna
Guliston davlat universiteti dotsenti Email:lola1981a@mail.ru Tel:+998974948134
Muxlisa Turdibekova
Guliston davlat universiteti talabasi
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Keywords

menthol, serin, prolin, leysin, fenilalanin, fizik-kimyoviy konstantalar, IR spektri, yangi hosilalar

Abstract

Ushbu maqolada menthol va ayrim aminokislotalar asosida sintez qilingan yangi organik birikmalarni olish sharoitlari, ularning tuzilmalari va fizik-kimyoviy xossalari bayon etilgan. Tadqiqot davomida olingan birikmalarning tashqi ko‘rinishi, agregat holati, suyuqlanish harorati kabi parametrlar o‘rganildi. Spektroskopik usullar, xususan, infraqizil (IR) spektr tahlili orqali yangi hosilalarning molekulyar tuzilmalari aniqlashtirildi. Olingan natijalar menthol asosida turli aminokislotalar bilan sintez qilingan birikmalar har xil xossalarga ega ekanligini ko‘rsatdi. Ushbu yangi birikmalar kelgusida biologik faollik bo‘yicha ham baholanishi mumkin.

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References

1. World Health Organization. Summary of WHO guidelines for the assessment of herbal medicines. Herbal Gram. 1993; 28:13–14.

2. Hamburger M, Hostettmann K. Bioactivity in plants: the link between phytochemistry and medicine. Phytochemistry. 1991 Jan 1; 30(12): 3864-74.

3. Rates SM. Plants as a source of drugs. Toxicon. 2001 May 1; 39(5): 603-13.

4. Tang Y, Zhu W, Chen K, Jiang H. New technologies in computer-aided drug design: Toward target identification and new chemical entity discovery. Drug Discovery Today: Technologies. 2006 Sep 1; 3(3): 307-13.

5. Shaker B, Ahmad S, Lee J, Jung C, Na D. In silico methods and tools for drug discovery. Computers in Biology and Medicine. 2021 Oct 1; 137: 104851.

6. Mishra KP, Ganju L, Sairam M, Banerjee PK, Sawhney RC. A review of high throughput technology for the screening of natural products. Biomedicine & Pharmacotherapy. 2008 Feb 1; 62(2): 94-8.

7. Chang Y, Hawkins BA, Du JJ, Groundwater PW, Hibbs DE, Lai F. A Guide to In Silico Drug Design. Pharmaceutics. 2023 Jan;15(1): 49.

8. Katsila T, Spyroulias GA, Patrinos GP, Matsoukas MT. Computational approaches in target identification and drug discovery. Computational and Structural Biotechnology Journal. 2016 Jan 1; 14: 177-84.

9. M.B. King, H. Al-Najjar, Chem. Eng. Sci. 29 (1974) 1003-1011.

10. M.B. King, Transactions of the Institution of Chemical Engineers 54 (1976) 54-60.

11. Sahoo MR, Marakanam SU, Varier RR. Development and Evaluation of Essential Oil-based Lozenges using Menthol and Eucalyptus and in vitro Evaluation of their Antimicrobial activity in S. aureus and E. coli. Research Journal of Pharmacy and Technology. 2022; 15(11): 5283-8.

12. Oz M, El Nebrisi EG, Yang KH, Howarth FC, Al Kury LT. Cellular and molecular targets of menthol actions. Frontiers in Pharmacology. 2017; 8: 472.