Vol. 1 No. 9 (2025), Articles
Vol. 1 No. 9 (2025)

SARATON HUJAYRALARINING METABOLIK O`ZGARISHLARI VA ULAR BILAN KURASHISH STRATEGIYALARI

Articles
Published 2025-05-27
Qurbonov Akobir Uyg’un o’g’li
Toshkent Tibbiyot Akademiyasi 4-kurs talabasi
Rahmonqulov Alferid To’lqin o’g’li
Toshkent Tibbiyot Akademiyasi 3-kurs talabasi
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Keywords

Kalit so‘zlar, saraton hujayralari, Warburg effekti, glutamin metabolizmi, lipid sintezi, saraton metabolizmi, zamonaviy tashxislash va davolash usullari.

Abstract

Ushbu maqolada saraton hujayralarining metabolik xususiyatlari, jumladan, Warburg effekti, glutamin metabolizmi va lipid sintezi jarayonlari ko‘rib chiqilgan. Metabolik o‘zgarishlarning saraton hujayralarining o‘sishi va yashash qobiliyatiga ta’siri, shuningdek, ushbu jarayonlarni nishonga oluvchi zamonaviy terapiya usullari batafsil tahlil qilingan. Tadqiqotlarda glyukoza, glikoliz, glutamin metabolizmi va lipogenezni nishonga olish strategiyalarining klinik amaliyotdagi ahamiyati ta’kidlangan. Saraton metabolizmini o‘rganish va nishonga olish orqali terapiyaning yangi yo‘nalishlarini rivojlantirish istiqbollari haqida va zamonaviy tashxislash va davolash usullari keltirilgan.

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References

Warburg, O. (1956). On the Origin of Cancer Cells. Science, 123(3191), 309-314.

2. DeBerardinis, R. J., & Cheng, T. (2010). Q&A: What’s so special about glutamine? Nature Reviews Cancer, 10(9), 686-695.

3. Menendez, J. A., & Lupu, R. (2007). Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nature Reviews Cancer, 7(10), 763-777.

4. Pelicano, H., Martin, D. S., Xu, R. H., & Huang, P. (2006). Glycolysis inhibition for anticancer treatment. Oncogene, 25(34), 4633-4646.

5. Dang, C. V. (2010). Rethinking the Warburg effect with Myc micromanaging glutamine metabolism. Cancer Research, 70(3), 859-862.

6. Mashima, T., & Tsuruo, T. (2002). De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy. British Journal of Cancer, 87(3), 277-282.

7. Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009). Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science, 324(5930), 1029-1033.

8. Tennant, D. A., Duran, R. V., & Gottlieb, E. (2010). Targeting metabolic transformation for cancer therapy. Nature Reviews Cancer, 10(4), 267-277.

9. Cairns, R. A., Harris, I. S., & Mak, T. W. (2011). Regulation of cancer cell metabolism. Nature Reviews Cancer, 11(2), 85-95.

10. Ward, P. S., & Thompson, C. B. (2012). Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell, 21(3), 297-308.