Vol. 3 No. 1 (2026), Articles
Vol. 3 No. 1 (2026)

INSULIN REZISTENTLIGIDA ENDOKRIN VA YALLIG‘LANISH PATOGENEZINING O‘ZARO BOG‘LIQLIGI

Articles
Published 2026-04-26
Musinjonov Alisherjon Qobiljon o’g’li
University of Business and Science Tibbiyot fakulteti tibbiyot kafedrasi o‘qituvchisi
Davlatova Oybarchin Ummatali qizi
University of Business and Science Tibbiyot fakulteti, DI-25-20 guruh talabasi
Ergasheva Muxlisa G’ulomjon qizi
University of Business and Science Tibbiyot fakulteti, DI-25-06 guruh talabasi
Mo’minjonova Marhaboxon Sirojiddin qizi
University of Business and Science Tibbiyot fakulteti, DI-25-24 guruh talabasi
Jakbarova Zilola Abdulaziz qizi
University of Business and Science Tibbiyot fakulteti, DI-25-06 guruh talabasi
PDF

Keywords

Endokrin tizim, qandli diabet, mikroangiopatiya, insulin rezistentligi, giperglikemiya, oksidlovchi stress, kapillyar o‘zgarishlar, patogenez, metabolik buzilishlar, to‘qima gipoksiyasi.

Abstract

Ushbu maqolada endokrin tizim buzilishlari va ularning patogenetik asoslari yoritilib, ayniqsa qandli diabetda rivojlanadigan mikroangiopatiyaning patomorfologik xususiyatlari tahlil qilindi. Endokrin omillar ta’sirida yuzaga keladigan metabolik o‘zgarishlar natijasida qon tomirlarining mikrotsirkulyator darajasida strukturaviy va funksional buzilishlar rivojlanishi ko‘rsatildi.

Tadqiqot davomida giperglikemiya, insulin rezistentligi va oksidlovchi stressning mikroangiopatiya shakllanishidagi o‘rni o‘rganildi. Ushbu omillar ta’sirida kapillyar devorining qalinlashuvi, bazal membrananing o‘zgarishi va to‘qimalarda gipoksiya rivojlanishi aniqlangan.

Olingan natijalar endokrin buzilishlarning patogenezini chuqurroq tushunish va ularning asoratlarini erta aniqlash hamda samarali davolash strategiyalarini ishlab chiqishda muhim ilmiy-amaliy ahamiyatga ega ekanligini ko‘rsatadi.

PDF

References

1. Karimov F.N., Xudoyarov A.A. Endokrin tizim kasalliklari va ularning patogenezi. – Toshkent: Tibbiyot nashriyoti, 2019.

2. Abdullayeva D.R. Qandli diabet va uning asoratlari. – O‘zbekiston tibbiyot jurnali, 2021.

3. Rahimov G‘.R., Ismoilov S.T. Patologik fiziologiya asoslari. – Toshkent, 2020.

4. Tursunov B.X. Diabetik mikroangiopatiya va uning klinik ahamiyati. – Samarqand davlat tibbiyot universiteti ilmiy ishlari, 2022.

5. Mirzayev A.K. Zamonaviy endokrinologiya asoslari. – Toshkent, 2020.

6. Kumar V., Abbas A.K., Aster J.C. Robbins & Cotran Pathologic Basis of Disease. – Elsevier, 2020.

7. American Diabetes Association. Standards of Medical Care in Diabetes. – Diabetes Care, 2023.

8. rownlee M. The pathobiology of diabetic complications: a unifying mechanism. – Nature, 2001.

9. Forbes J.M., Cooper M.E. Mechanisms of diabetic complications. – Physiological Reviews, 2013.

10. Giacco F., Brownlee M. Oxidative stress and diabetic complications. – Circulation Research, 2010.

11. Tesfaye S., Boulton A.J.M.Diabetic neuropathy: mechanisms and management. – The Lancet Neurology, 2005.

12. Fowler M.J.Microvascular and macrovascular complications of diabetes. – Clinical Diabetes, 2008.