Keywords
Abstract
Steroid-indutsirlangan giperglikemiya va steroid diabet glyukokortikoid preparatlarning uzoq muddat qo‘llanilishi natijasida yuzaga keladigan murakkab metabolik buzilishlardan biri hisoblanadi. Ushbu maqolada steroid gormonlarning glyukoza almashinuviga ta’siri, insulin rezistentlik rivojlanish mexanizmlari, pankreatik beta-hujayralar faoliyatining pasayishi, klinik belgilari, diagnostik mezonlari hamda zamonaviy davolash va profilaktika yondashuvlari batafsil tahlil qilindi. Tadqiqotlar shuni ko‘rsatadiki, glyukokortikoidlar organizmda glyukoneogenezni kuchaytirib, periferik to‘qimalarda glyukozaning utilizatsiyasini kamaytiradi va insulin signalizatsiyasini izdan chiqaradi. Natijada giperglikemiya rivojlanadi va ayrim hollarda to‘liq shakllangan steroid diabetga o‘tadi. Ushbu holat ko‘pincha yashirin kechishi sababli erta aniqlash va muntazam monitoring muhim ahamiyat kasb etadi.
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