Keywords
Abstract
B12 vitamini yetishmovchiligi anemiyasi megaloblastik anemiyalar guruhiga kirib, DNK sintezining buzilishi natijasida rivojlanadi. Mazkur maqolada kobalamin metabolizmi, gematologik o‘zgarishlarning patofiziologik mexanizmlari hamda nevrologik asoratlarning rivojlanish sabablari adabiyotlar tahlili asosida yoritilgan. Shuningdek, O‘zbekiston Respublikasi Sog‘liqni saqlash vazirligi va respublika ixtisoslashtirilgan gematologiya markazlarining ochiq ma'lumotlari asosida respublikada B12 tanqisligi anemiyasining uchrash darajasi, mintaqaviy xususiyatlari va xavf guruhlari tahlil qilingan. B12 tanqisligi suyak iligida megaloblastoz, periferik qonda makrotsitoz va gipersegmentlangan neytrofillar paydo bo‘lishiga olib keladi. Bundan tashqari, metilmalon kislotasi (MMK) to‘planishi va mielin sintezining buzilishi natijasida orqa miyaning orqa va yon ustunlarida o‘tkir osti kombinatsiyalashgan degeneratsiya rivojlanadi.
References
Kasper D.L., Fauci A.S., Hauser S.L., et al. (2018). Harrison's Principles of Internal Medicine (20th ed.). McGraw-Hill Education.
2. Hoffbrand A.V., Moss P.A.H. (2015). Hoffbrand's Essential Haematology (7th ed.). Wiley-Blackwell.
3. Stabler S.P. (2013). Vitamin B12 deficiency. New England Journal of Medicine, 368(2), 149-160.
4. Green R., Allen L.H., Bjørke-Monsen A.L., et al. (2017). Vitamin B12 deficiency. Nature Reviews Disease Primers, 3, 17040.
5. Allen L.H. (2009). How common is vitamin B-12 deficiency? American Journal of Clinical Nutrition, 89(2), 693S-696S.
6. O‘zbekiston Respublikasi Sog‘liqni saqlash vazirligi (2023). Respublika ixtisoslashtirilgan gematologiya ilmiy-amaliy tibbiyot markazining 2020-2023 yillardagi statistik hisobotlari. Toshkent.
7. Karimov X.Y., Alimova D.A., Rasulov A.S. (2023). Toshkent viloyati aholisi orasida B12 vitamini yetishmovchiligining tarqalishi. O‘zbekiston tibbiyot jurnali, 2(45), 34-39.
8. Kurbanov A.B., Matkarimov K.J., Saparova Z.A. (2022). Qoraqalpog‘iston Respublikasi aholisida mikroelementozlar va vitamin yetishmovchiligi muammolari. Ekologiya va salomatlik, 1(12), 23-28.
9. Lindenbaum J., Healton E.B., Savage D.G., et al. (1988). Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. New England Journal of Medicine, 318(26), 1720-1728.
10. Nielsen M.J., Rasmussen M.R., Andersen C.B., et al. (2012). Vitamin B12 transport from food to the body's cells—a sophisticated, multistep pathway. Nature Reviews Gastroenterology & Hepatology, 9(6), 345-354.
11. Shane B. (2008). Folate and vitamin B12 metabolism: overview and interaction with riboflavin, vitamin B6, and polymorphisms. Food and Nutrition Bulletin, 29(2 Suppl), S5-S16.
12. Banerjee R., Ragsdale S.W. (2003). The many faces of vitamin B12: catalysis by cobalamin-dependent enzymes. Annual Review of Biochemistry, 72, 209-247.
13. Воробьев А.И. (2019). Руководство по гематологии (4-е изд.). Москва: Ньюдиамед.
14. Koury M.J., Ponka P. (2004). New insights into erythropoiesis: the roles of folate, vitamin B12, and iron. Annual Review of Nutrition, 24, 105-131.
15. Aslinia F., Mazza J.J., Yale S.H. (2006). Megaloblastic anemia and other causes of macrocytosis. Clinical Medicine & Research, 4(3), 236-241.
16. Carmel R. (2008). How I treat cobalamin (vitamin B12) deficiency. Blood, 112(6), 2214-2221.
17. Scalabrino G. (2009). The multi-faceted basis of vitamin B12 (cobalamin) neurotrophism in adult central nervous system: Lessons learned from its deficiency. Progress in Neurobiology, 88(3), 203-220.
18. Savage D.G., Lindenbaum J., Stabler S.P., Allen R.H. (1994). Sensitivity of serum methylmalonic acid and total homocysteine determinations for diagnosing cobalamin and folate deficiencies. American Journal of Medicine, 96(3), 239-246.
19. Weir D.G., Scott J.M. (1999). Brain function in the elderly: role of vitamin B12 and folate. British Medical Bulletin, 55(3), 669-682.
20. Hemmer B., Glocker F.X., Schumacher M., et al. (1998). Subacute combined degeneration: clinical, electrophysiological, and magnetic resonance imaging findings. Journal of Neurology, Neurosurgery & Psychiatry, 65(6), 822-827.
21. Pant S.S., Asbury A.K., Richardson E.P. (1968). The myelopathy of pernicious anemia. A neuropathological reappraisal. Acta Neurologica Scandinavica, 44(S35), 1-36.
22. Briani C., Dalla Torre C., Citton V., et al. (2013). Cobalamin deficiency: clinical picture and radiological findings. Nutrients, 5(11), 4521-4539.
23. Юсупова Н.А., Каримов М.Ш. (2023). B12-дефицитная анемия в Узбекистане: клинико-эпидемиологическая характеристика. Гематология и трансфузиология, 68(2), 145-152.
24. Shamsiev A.M., Rahimov N.M., Tursunov X.X. (2023). Surunkali gastrit bilan og‘rigan bemorlarda B12 vitamini so‘rilishi buzilishlarining diagnostikasi. Samarqand tibbiyot jurnali, 3(28), 56-61.
25. Nazarova J.A., Murodov A.T. (2024). Periferik neyropatiyalarning etiologik strukturasida B12 vitamini yetishmovchiligining o‘rni. Nevrologiya va neyroxirurgiya, 1(19), 42-47.
26. Solomon L.R. (2016). Disorders of cobalamin (vitamin B12) metabolism: emerging concepts in pathophysiology, diagnosis and treatment. Blood Reviews, 21(3), 113-130.
27. Healton E.B., Savage D.G., Brust J.C., et al. (1991). Neurologic aspects of cobalamin deficiency. Medicine, 70(4), 229-245.
28. O‘zbekiston Respublikasi Sog‘liqni saqlash vazirligi (2019). O‘zbekiston Respublikasida anemiyalar profilaktikasi va davolash bo‘yicha milliy klinik protokol. Toshkekent.
29. Дворецкий Л.И. (2021). B12-дефицитная анемия в практике врача. Терапевтический архив, 93(4), 424-431.
30. Идельсон Л.И. (2020). Анемии: патогенез, диагностика, лечение. Москва: Медицина.