Vol. 1 No. 9 (2025), Articles
Vol. 1 No. 9 (2025)

FARMATSEVTIK SHAKLLARNING BIOLOGIK O‘ZLASHTIRILISHIGA TA’SIR ETUVCHI OMILLAR

Articles
Published 2025-10-11
O`ktamova N.B.
Toshken shahar Alfraganus universiteti Tibbiyot fakulteti Davolash ishi yoʻnalishi 3- bosqich talabasi,
Boymuratov F.T.
Toshken shahar Alfraganus universiteti Tibbiyot fakulteti farmatsevtika va kimyo kafedrasi dotsenti
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Keywords

Farmatsevtik shakl, bioavailability, so‘rilish, dori modda, yordamchi modda, farmakokinetika, metabolizm, membrana o‘tkazuvchanligi, nanoformulalar, terapevtik samaradorlik.

Abstract

Maqolada farmatsevtik shakllarning biologik o‘zlashtirilishiga ta’sir etuvchi asosiy omillar — dori moddasining fizik-kimyoviy xususiyatlari, yordamchi moddalarning roli, tayyorlash texnologiyasi va organizmning fiziologik holati haqida so‘z yuritiladi. Dori vositasining terapevtik samaradorligi ko‘p jihatdan uning biologik o‘zlashtirilish darajasiga bog‘liq bo‘lib, bu jarayon dori moddasining so‘rilish, taqsimlanish, metabolizm va chiqarilish bosqichlarida yuz beradi. Bioavailability (biologik o‘zlashtirilish) ko‘rsatkichini oshirish farmatsevtik texnologiyaning asosiy maqsadlaridan biridir. Maqolada turli farmatsevtik shakllarning — tabletkalar, kapsulalar, inyeksiya eritmalari, suspenziya, aerozol, liposomal va nanoformalarning — o‘zlashtirilishdagi farqlari hamda ularni yaxshilash strategiyalari yoritilgan.

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