Vol. 1 No. 8 (2025), Articles
Vol. 1 No. 8 (2025)

THYROID HORMONES AND THEIR IMPACT ON PREGNANCY: EFFECTS AND RISKS

Articles
Published 2025-09-23
Barnoxonim Yuldasheva
Alfraganus University, Faculty of Medicine 4th-year Medical Student, Clinical Internship
Rahmatullayeva Aziza Farxodovna
Scientific Advisor: Gynecologist, Pediatric Gynecologist
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Keywords

Thyroid hormones, pregnancy, hypothyroidism, hyperthyroidism, maternal-fetal health, pregnancy complications, fetal development, endocrine regulation

Abstract

Thyroid hormones play a crucial role in maternal and fetal health during pregnancy. Proper thyroid function ensures normal fetal neurodevelopment, regulates maternal metabolism, and supports placental function. Both hypothyroidism and hyperthyroidism can lead to adverse pregnancy outcomes, including miscarriage, preterm birth, preeclampsia, and impaired neurocognitive development in the offspring. This article reviews the physiological role of thyroid hormones during pregnancy, their regulatory mechanisms, and the potential maternal and fetal risks associated with thyroid dysfunction. Understanding these effects is essential for early diagnosis, monitoring, and appropriate therapeutic interventions to optimize pregnancy outcomes.
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References

1. Alexander, E. K., Pearce, E. N., Brent, G. A., et al. (2017). 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. Thyroid, 27(3), 315–389.

2. Glinoer, D. (1997). The regulation of thyroid function in pregnancy: pathways of endocrine adaptation from physiology to pathology. Endocrine Reviews, 18(3), 404–433.

3. Stagnaro-Green, A., Abalovich, M., Alexander, E., et al. (2011). Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid, 21(10), 1081–1125.

4. Korevaar, T. I., Medici, M., Visser, W. E., et al. (2017). Thyroid disease in pregnancy: new insights in diagnosis and clinical management. Nature Reviews Endocrinology, 13, 610–622.

5. Casey, B. M., Dashe, J. S., Wells, C. E., et al. (2005). Subclinical hypothyroidism and pregnancy outcomes. Obstetrics & Gynecology, 105(2), 239–245.

6. Li, C., Shan, Z., Teng, W., et al. (2010). Maternal subclinical hypothyroidism, thyroid autoimmunity, and pregnancy outcomes. Journal of Clinical Endocrinology & Metabolism, 95(11), 5260–5266.

7. Brent, G. A. (2012). Maternal thyroid function: Interpretation of laboratory tests and management of thyroid disorders in pregnancy. Clinical Obstetrics and Gynecology, 55(2), 375–392.