Vol. 2 No. 8 (2026), Articles
Vol. 2 No. 8 (2026)

МОЛЕКУЛЯРНЫЕ МЕХАНИЗМЫ И ЭПИГЕНЕТИЧЕСКАЯ РЕГУЛЯЦИЯ ПРИ НЕЙРОДЕГЕНЕРАТИВНЫХ И ПСИХИЧЕСКИХ ПАТОЛОГИЯХ

Articles
Published 2026-06-29
Кадырбергенов Руслан Бердумратович
Учреждение образования «Ташкентский Государственный Медицинский Университет» г. Ташкент, Республика Узбекистан
Юлдашева Зимфира Зокировна
Научный руководитель: старший преподаватель Учреждение образования «Ташкентский Государственный Медицинский Университет» г. Ташкент, Республика Узбекистан
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Keywords

Synaptic transmission, intracellular signaling, CREB, BDNF, synaptic plasticity, transcriptional regulation, chromatin modification.

Abstract

This paper analyzes the role of signaling molecules in memory formation and cognitive activity. It is shown that these processes are based on a sequence of biochemical reactions initiated by synaptic transmission and leading to the formation of functionally significant molecules. A particularly important role is played by an integrated system of signaling mechanisms, including transduction, transcriptional, epigenetic, and neurotrophic components.

It is emphasized that disruption of their coordinated functioning is a key factor in the development of cognitive disorders and memory impairment, accompanied by social maladjustment. The results of experimental and clinical studies demonstrating the importance of multilevel neurosignaling in aging, Alzheimer's disease, and depression are reviewed.

The potential of signaling molecules as promising targets for the development of new therapeutic approaches is highlighted.

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