Keywords
Abstract
Timus bezi immun tizimning markaziy organlaridan biri bo‘lib, T-limfotsitlarning differensiallanishi va yetilishida muhim rol o‘ynaydi. Yosh ortishi bilan timus bezida involyutsion o‘zgarishlar rivojlanib, uning gistologik tuzilishi va funksional faolligi pasayadi. Ushbu maqolaning maqsadi timus bezining yoshga bog‘liq gistologik o‘zgarishlarini va ularning immun tizim faoliyatiga ta’sirini o‘rganishdan iborat. Tadqiqot davomida zamonaviy ilmiy adabiyotlar tahlil qilindi va timus involyutsiyasining asosiy mexanizmlari baholandi. Natijalarga ko‘ra, yosh ortishi bilan timus parenximasining yog‘ to‘qimasi bilan almashinishi, kortikal qismning kichrayishi va T-limfotsitlar hosil bo‘lishining pasayishi kuzatiladi. Ushbu jarayonlar immunitetning susayishiga va infeksion hamda autoimmun kasalliklar rivojlanish xavfining oshishiga olib keladi.
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