Vol. 2 No. 1 (2025), Articles
Vol. 2 No. 1 (2025)

STRESS VA IMMUN TIZIMI O‘RTASIDAGI O‘ZARO BOG‘LIQLIK: KLINIK KUZATUVLAR ASOSIDA TAHLIL

Articles
Published 2025-10-11
O`ktamova N.B.
Toshken shahar Alfraganus universiteti Tibbiyot fakulteti Davolash ishi yoʻnalishi 3- bosqich talabasi,
Boymuratov F.T.
Toshken shahar Alfraganus universiteti Tibbiyot fakulteti farmatsevtika va kimyo kafedrasi dotsenti
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Keywords

Stress, immun tizimi, kortizol, limfotsitlar, HPA o‘qi, sitokinlar, psixonevroimmunologiya, yallig‘lanish, klinik kuzatuv, adaptatsiya.

Abstract

Mazkur maqolada stress holatining inson immun tizimiga ko‘rsatadigan ta’siri, ularning o‘zaro bog‘liqligi va klinik kuzatuvlar natijalari asosida tahlil qilingan. Stress organizmning fiziologik va psixologik muvozanatini buzuvchi omil bo‘lib, u gipotalamo-gipofizar-buyrak usti o‘qi (HPA o‘qi) orqali immun javobni susaytiradi yoki o‘zgartiradi. Tadqiqotlar shuni ko‘rsatadiki, uzoq davom etuvchi stress limfotsitlar, T-hujayralar va NK-hujayralar faolligini pasaytirib, yallig‘lanish mediatorlarining disbalansiga olib keladi. Shu orqali organizm infeksion va autoimmun kasalliklarga nisbatan zaiflashadi. Klinik kuzatuvlarga ko‘ra, stress bilan bog‘liq immun o‘zgarishlar depressiya, yurak-qon tomir kasalliklari, hatto onkologik jarayonlarning rivojlanishida ham muhim rol o‘ynaydi. Maqolada stressni kamaytiruvchi psixologik, farmakologik va fizioterapevtik yondashuvlarning immun funksiyalarni tiklashdagi o‘rni ham yoritilgan.

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