Abstract
Metabolic syndrome (MetS) is a multifactorial disorder characterized by abdominal obesity, insulin resistance, impaired glucose metabolism, dyslipidemia and arterial hypertension. In addition to cardiovascular and metabolic complications, increasing evidence indicates that MetS may be associated with cognitive impairment, anxiety, depression, sleep disturbances and reduced quality of life. These neuropsychological manifestations may negatively influence treatment adherence and lifestyle modification. Therefore, their early detection and comprehensive management are clinically important.
References
1. Alberti K.G.M.M., Eckel R.H., Grundy S.M., et al. Harmonizing the metabolic syndrome: A joint interim statement. Circulation. 2009;120:1640–1645.
2. Grundy S.M. Metabolic syndrome update. Trends in Cardiovascular Medicine. 2016;26:364–373.
3. Reaven G.M. Role of insulin resistance in human disease. Diabetes. 1988;37:1595–1607.
4. Yates K.F., Sweat V., Yau P.L., Turchiano M.M., Convit A. Impact of metabolic syndrome on cognition and brain. Arteriosclerosis, Thrombosis, and Vascular Biology. 2012;32:2060–2067.
5. Cooper C., Sommerlad A., Welsh J., et al. Metabolic syndrome and cognition: A systematic review. Ageing Research Reviews. 2022.
6. Scherer T., Hill J.A. Obesity, diabetes, and cognitive decline: A role for inflammation. Molecular Metabolism. 2016;5:271–280.
7. Lian Y., Yuan Q., Wang G., Tang F. Association between sleep quality and metabolic syndrome: A systematic review and meta-analysis. Psychiatry Research. 2019;274:66–74.
8. Nasreddine Z.S., Phillips N.A., Bédirian V., et al. The Montreal Cognitive Assessment, MoCA. Journal of the American Geriatrics Society. 2005;53:695–699.
9. Zigmond A.S., Snaith R.P. The Hospital Anxiety and Depression Scale. Acta Psychiatrica Scandinavica. 1983;67:361–370.
10. Lovibond P.F., Lovibond S.H. The structure of negative emotional states. Behaviour Research and Therapy. 1995;33:335–343.
11. Herdman M., Gudex C., Lloyd A., et al. Development of the EQ-5D-5L. Quality of Life Research. 2011;20:1727–1736.
12. Hong D.Y., et al. Relationship between brain metabolic disorders and cognitive impairment: LDL receptor defect. International Journal of Molecular Sciences. 2022;23:8384.
13. Pugazhenthi S., Qin L., Reddy P.H. Common neurodegenerative pathways in obesity, diabetes, and Alzheimer's disease. BBA. 2017;1863:1037–1045.
14. Cukierman-Yaffe T., Gerstein H.C., Williamson J.D., et al. Glycemic control and cognitive function. Diabetes Care. 2009;32:221–226.
15. Kivipelto M., Ngandu T., Fratiglioni L., et al. Obesity and vascular risk factors at midlife and risk of dementia. Archives of Neurology. 2005;62:1556–1560.
16. Whitmer R.A., Sidney S., Selby J., Johnston S.C., Yaffe K. Midlife cardiovascular risk factors and dementia. Neurology. 2005;64:277–281.
17. Craft S. The role of metabolic disorders in Alzheimer disease and vascular dementia. Archives of Neurology. 2009;66:300–305.
18. Van den Berg E., Kloppenborg R.P., Kessels R.P.C., Kappelle L.J., Biessels G.J. Metabolic risk factors and cognition. Dementia and Geriatric Cognitive Disorders. 2009;27:141–148.
19. Grundy S.M., Cleeman J.I., Daniels S.R., et al. Diagnosis and management of metabolic syndrome. Circulation. 2005;112:2735–2752.
20. Power M., Harper A., Bullinger M. The WHOQOL-100. Health Psychology. 1999;18:495–505.